Cell Unit

Objectives

The Cell Unit specializes in performing cell-based tests and analyses for R&D, particularly in the fields of cancer and infectious diseases.

Equipped with state-of-the-art technology, the Cell Unit provides accredited diagnostic tests for clinical trials, providing adding value to SMEs and researchers.

Areas of impact and applications in the field

Recent advances in bacterial and mammalian cell engineering include the development of cells that function in biological samples or within the body as minimally invasive diagnostics or theranostics for the real-time regulation of complex pathological conditions. Ex-vivo and in-vivo cell-based biosensors and therapeutics have been developed to target various diseases including cancer.

A significant milestone in the field of theranostic cell engineering was the 2017 FDA approval of tisagenlecleucel, the first gene therapy to be approved in the USA. Considering the above, this facility will work on preclinical applications of mammalian sensing and drug delivery platforms and underlying biological designs that could lead to innovative cell diagnostics and therapeutics.

There is a growing need for novel, specific, sensitive, and compelling diagnostic and treatment procedures in infectious diseases. Synthetic systems and devices are evolving into robust tools for treating human infections. The advancement of synthetic biology provides  efficient, accurate, and cost-effective platforms for detecting, preventing, and treating infectious diseases .

Beckman Coulter DxFlex Cytometer
Beckman Coulter DxFlex Cytometer
Confocal microscope: Leica – Stellaris 8
Live Cell Analysis System: Sartorius Incucyte SX5
Fluorescence microscope: Leica - DMi8
  • Areas of impact and applications in the field

    Regarding cancer research, synthetic biology seeks to re-design biological systems to perform novel functions in a predictable way. Recent advances in bacterial and mammalian cell engineering include the development of cells that function in biological samples or within the body as minimally invasive diagnostics or theranostics for the real-time regulation of complex pathological conditions. Ex-vivo and in-vivo cell-based biosensors and therapeutics have been developed to target a wide range of diseases including cancer.

    A major milestone in the field of theranostic cell engineering was the 2017 FDA approval of tisagenlecleucel, the first gene therapy to be approved in the USA. Considering the above, this facility will work on preclinical applications of mammalian sensing and drug delivery platforms as well as underlying biological designs that could lead to new classes of cell diagnostics and therapeutics.

    In the context of infectious diseases, there is a growing need for novel, specific, sensitive, and effective diagnostic and treatment procedures. Synthetic systems and devices are evolving into strong tools for treating human infections. The advancement of synthetic biology provides platforms for detecting and preventing infectious diseases that are efficient, accurate, and cost-effective.

Services

  • In vitro cytotoxicity tests (MTT)
  • Agar-diffusion
  • Minimal Residual Disease (MRD)
  • Flow cytometry
  • List of Equipments

    Equipment name
    Make
    Model
    Photo
    Equipment name:
    Flow cytometer with sorter
    Make:
    Beckman Coulter
    Model:
    DxFlex Cytometer + CytoFlex SRT Sorter
    Equipment name:
    Confocal microscope
    Make:
    Leica
    Model:
    Stellaris 8
    Equipment name:
    Fluorescence microscope
    Make:
    Leica
    Model:
    DMi8
    Equipment name:
    Refrigerator (+4C)
    Make:
    Frimed
    Model:
    AF140
    Equipment name:
    CO2 incubator
    Make:
    Memmert
    Model:
    ICO 150
    Equipment name:
    Class II Cabinet
    Make:
    Miprolab
    Model:
    Msafe 120
    Equipment name:
    Live Cell Analysis System
    Make:
    Sartorius
    Model:
    Incucyte SX5
    Equipment name:
    Inverted microscope
    Make:
    Leica
    Model:
    DMi8
    Equipment name:
    High-speed centrifuge
    Make:
    Hermle
    Model:
    Z32 HK
    Equipment name:
    Cell counter
    Make:
    Bio-Rad
    Model:
    TC20 Automated

    Staff

    Dr. Klara Dalva
    Ankara University Technology Transfer Office
    Unit Lead
    research, development, R&D, cell core, tissue core, laboratory, healthcare, theranostics products, healthcare industry, innovation, health, diagnosis
    AnkaTheraHub is dedicated to promoting the R&D capacity of the healthcare industry in Türkiye, with a focus on SMEs to produce high-added and high-tech innovative theranostics products in the field of cancer and infectious diseases.