Upstream and Downstream Processes Unit

Objectives

The Upstream and Downstream Processes Unit offers services for generating antibodies, peptide, plasmid, and viral and non-viral products for therapeutic strategies.

Equipped with state-of-the-art technology, AnkaTheraHub’s Upstream and Downstream Processes Unit provides accredited process development and process optimization services to the pharma industry.

Benefits

The upstream and downstream processes unit provides several benefits including integrated workflow, efficient resource utilization, controlled environment for cell culture and purification, scalability, quality assurance through better monitoring and control, cost-effectiveness via streamlined operations, and flexibility to adapt to changing production demands, ultimately enhancing efficiency, product quality, and cost-effectiveness in the production of biopharmaceuticals and other biological products.

Bioreactor and purification unit for Cell products (for non-viral products)
Bioreactor and purification unit for Cell products (for viral products)
Biosafety cabinet
CO2 incubator

  • Areas of impact and applications in the field

    Regarding cancer research, synthetic biology seeks to re-design biological systems to perform novel functions in a predictable way. Recent advances in bacterial and mammalian cell engineering include the development of cells that function in biological samples or within the body as minimally invasive diagnostics or theranostics for the real-time regulation of complex pathological conditions. Ex-vivo and in-vivo cell-based biosensors and therapeutics have been developed to target a wide range of diseases including cancer.

    A major milestone in the field of theranostic cell engineering was the 2017 FDA approval of tisagenlecleucel, the first gene therapy to be approved in the USA. Considering the above, this facility will work on preclinical applications of mammalian sensing and drug delivery platforms as well as underlying biological designs that could lead to new classes of cell diagnostics and therapeutics.

    In the context of infectious diseases, there is a growing need for novel, specific, sensitive, and effective diagnostic and treatment procedures. Synthetic systems and devices are evolving into strong tools for treating human infections. The advancement of synthetic biology provides platforms for detecting and preventing infectious diseases that are efficient, accurate, and cost-effective.

Services

  • Purification of antibody or recombinant protein from a supernatant or protein extract, concentration and final formulation
  • Analysis of mycoplasma contamination
  • Analysis of endotoxin contamination

    • List of Equipments

    Equipment name
    Make
    Model
    Photo
    Equipment name:
    Bioreactor and purification unit for Cell products (for non-viral products)
    Make:
    Sartorius
    Model:
    Biostat B 5L MO
    Equipment name:
    Bioreactor and purification unit for Cell products (for viral products)
    Make:
    Sartorious
    Model:
    Biostat B 5L CC
    Equipment name:
    Biosafety Cabinet
    Make:
    Labogene
    Model:
    Class II Cabinet Mars 1200
    Equipment name:
    CO2 incubator
    Make:
    Memmert
    Model:
    ICO 150

    Staff

    Dr. Gizem Sonugür
    Dr. Gizem Sonugür
    Ankara University
    Unit Lead
    upstream-and-downstream-processes-unit
    AnkaTheraHub is dedicated to promoting the R&D capacity of the healthcare industry in Türkiye, with a focus on SMEs to produce high-added and high-tech innovative theranostics products in the field of cancer and infectious diseases.