Hedefler
Antikor ve Peptit Birimi, antikor ve peptitin laboratuvar düzeyinde in-siliko tasarımına ve üretimine odaklanmaktadır.
Sahadaki uygulamaları ve etki alanları
Antikor ve Peptit Birimi, laboratuvar düzeyinde antikor ve peptit tasarlamak ve üretmek için gereklidir. Antikor bazlı hedefe yönelik tedaviler kanser tedavisinde giderek daha önemli hale gelmektedir. Bir antikorun teşhis ve tedavi potansiyelini birleştiren antikor teranostiği, bu tesis için bir başka potansiyel araştırma alanıdır.
Areas of impact and applications in the field
Regarding cancer research, synthetic biology seeks to re-design biological systems to perform novel functions in a predictable way. Recent advances in bacterial and mammalian cell engineering include the development of cells that function in biological samples or within the body as minimally invasive diagnostics or theranostics for the real-time regulation of complex pathological conditions. Ex-vivo and in-vivo cell-based biosensors and therapeutics have been developed to target a wide range of diseases including cancer.
A major milestone in the field of theranostic cell engineering was the 2017 FDA approval of tisagenlecleucel, the first gene therapy to be approved in the USA. Considering the above, this facility will work on preclinical applications of mammalian sensing and drug delivery platforms as well as underlying biological designs that could lead to new classes of cell diagnostics and therapeutics.
In the context of infectious diseases, there is a growing need for novel, specific, sensitive, and effective diagnostic and treatment procedures. Synthetic systems and devices are evolving into strong tools for treating human infections. The advancement of synthetic biology provides platforms for detecting and preventing infectious diseases that are efficient, accurate, and cost-effective.
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